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  • Return to More On Orthopaedic Medicine > Individual Prolotherapy Study Summaries > Knee Arthritis

    Osteoarthritis of Knee PRP Kon et al (2009)

    Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Canacchi A, Fornasari PM, Giannini S, Marcacci M. Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 2010; 18(4):472-479.

    Dr. Reeves' Notes:  PRP was utilized X 3 for patients with moderate knee arthritis with good results for 6 months and then slowly recurring symptoms. Blood was drawn and samples prepared and frozen and then thawed for 2nd and 3rd injections. This study was a safety study showing results in 115 knees. Knees with degenerative chrondropathy did better than those with early OA and those with advanced OA clearly did not do as well. 

    A PDF version of the study is available here.

    The abstract of this study on Knee Osteoarthritis is available here, with a copy of the content below.

    Abstract Platelet-rich plasma (PRP) is a natural concentrate of autologous blood growth factors experimented in different fields of medicine in order to test its potential to enhance tissue regeneration. The aim of our study is to explore this novel approach to treat degenerative lesions of articular cartilage of the knee. One hundred consecutive patients, affected by chronic degenerative condition of the knee, were treated with PRP intra-articular injections (115 knees treated). The procedure consisted of 150-ml of venous blood collected and twice centrifugated: 3 PRP units of 5 ml each were used for the injections. Patients were clinically prospectively evaluated before and at the end of the treatment, and at 6 and 12 months follow-up. IKDC, objective and subjective, and EQ VAS were used for clinical evaluation. Statistical analysis was performed to evaluate the significance of sex, age, grade of OA and BMI. A statistically significant improvement of all clinical scores was obtained from the basal evaluation to the end of the therapy and at 612 months follow-up (P\0.0005). The results remained stable from the end of the therapy to 6 months follow up, whereas they became significantly worse at 12 months follow up (P = 0.02), even if still significantly higher respect to the basal level (P\0.0005). The preliminary results indicate that the treatment with PRP injections is safe and has the potential to reduce pain and improve knee function and quality of live in younger patients with low degree of articular degeneration.


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