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  • Return to More On Orthopaedic Medicine > Individual Prolotherapy Study Summaries > Low Back Pain

    Chronic LBP PDG: Ongley et al (1987) Significant evidence for superior effect of the inflammatory proliferant solution over saline needling in chronic low back pain

    Ongley MJ, Klein RG, Dorman TA, et al: A new approach to the treatment of chronic low back pain. Lancet 2:143, 1987.

    Dr. Reeves' Notes:  Despite better-than-placebo improvement in the control group, the first two blinded studies of chronic low back pain (using phenol/dextrose/glycerin as active solution) demonstrated significant (P < .001) Ongley MJ, Klein RG, Dorman TA, et al: A new approach to the treatment of chronic low back pain. Lancet 2:143, 1987. and near significant (P = .056) Klein RG, Bjorn CE, DeLong B, et al: A randomized double-blind trial of dextrose-glycerine-phenol injections for chronic low back pain. J Spinal Disord 6:23, 1993. evidence for superior effect of the inflammatory proliferant solution over saline needling (Ongley et al) and anesthetic needling (Klein et al). These two studies were weakened somewhat by multiple simultaneous treatments, although the injection solution was the only significant difference between the two groups.


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